Methanogenesis associated with altered microbial production of short-chain fatty acids and human-host metabolizable energy.

ABSTRACT: Methanogens are methane-producing, hydrogen-oxidizing (i.e. hydrogenotrophic) archaea. Numerous studies have associated methanogens with obesity, but these results have been inconsistent. One link to metabolism may be methanogens' hydrogen-oxidizing ability, thus reducing hydrogen partial pressure and thermodynamically enhancing fermentation of sugars to short-chain fatty acids (SCFAs) that the host can absorb. Because research linking methanogenesis to human metabolism is limited, our goal with this exploratory analysis was to investigate relationships between methanogens and other hydrogenotrophs, along with the association of methanogens with human metabolizable energy (ME). Using results from a randomized crossover feeding study including a western diet and a high-fiber diet, well-char

SUBMITTER: Dirks B 

PROVIDER: S-EPMC12156016 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature