Prognosis of Breast Cancer in European female adolescents and young adults (AYAs): EUROCARE-6 retrospective cohort results.

ABSTRACT:

Background

Breast cancer (BC) is the most common malignancy in AYA (15-39 years) females and is more aggressive than in adult women (40-69 years). However, an updated overview on BC in AYAs and how it differs from BC in adult women is lacking.

Methods

We used data from the EUROCARE-6 study to calculate incidence rates (IRs) of BC in AYA and adult women over the period 2001-2013 in Europe. We estimated 5-year and 10-year relative survival (RS) using period analysis. Stage at diagnosis distribution and conditional RS (CS) were used to investigate survival differences. We also reported cumulative incidence of multiple primary neoplasms (MPNs) in AYAs.

Results

The IR of BC in Europe was ∼18 per 100,000 in AYA females and more than ten-fold higher in adult women. Most BC c

SUBMITTER: Bernasconi A 

PROVIDER: S-EPMC12156211 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature