Bioassay-Guided Isolation and Active Compounds Identification of the AntiDiabetic Fractions of <i>Centaurea calcitrapa</i> Extract and the Predicted Interaction Mechanism.

ABSTRACT: Centaurea calcitrapa is a well-known plant with antioxidant, anti-proliferative, and antimicrobial properties. The plant contains various phenolic compounds, flavonoids, and other bioactive molecules contributing to its medicinal properties. However, little is known about its antidiabetic activity. The study's purpose is the isolation and identification of active compounds of C. calcitrapa aerial parts in diabetic rats induced by streptozotocin. The ethyl acetate extract (E2) was separated into eight subfractions by column chromatography. The subfractions were evaluated for their antidiabetic activity using diabetic-induced rats. The most active subtraction was purified, and the active compounds were identified using UV spectrophotometry, Fourier Transform Infrared Spectrosco

SUBMITTER: Kadhim HM 

PROVIDER: S-EPMC12156352 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature