Cucurbitane Glycosides and Their Potential Anti-Inflammatory Activities from <i>Hemsleya chinensis</i> Tubers.

ABSTRACT: Hemsleya chinensis tubers, abundantly produced in southwestern China, are commonly used as a folk medicine that excel in anti-inflammation to treat enteritis, bronchitis, and tonsillitis. In this study, three previously undescribed cucurbitane glycosides, hemchinins G-H (1-3), that were characterized by the presence of four glucose substitutions, as well as eleven ones with one to three β-glucoses, were isolated from the tubers of H. chinensis. The structures were confirmed using comprehensive UV, IR, HR-ESI-MS, and NMR analyses, and absolute configurations were determined through a comparison of calculated and experimental ECD after acid hydrolysis. Compounds 1-3 showed NO inhibition effects on LPS-induced RAW 264.7 cells. Finally, molecula

SUBMITTER: Chi J 

PROVIDER: S-EPMC12156364 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature