Exploring the Role of <i>SIRT1</i> Polymorphisms in Colorectal Cancer Risk: A Case-Control Study.

ABSTRACT: Background: Colorectal cancer (CRC), the most common malignancy of the gastrointestinal tract, is the second leading cause of cancer-related deaths worldwide. In this context, investigating low-penetrance gene variants associated with the increased risk of CRC represents a novel and crucial approach to enhancing prevention strategies and clinical surveillance. By focusing on these genetic variants, there is potential for more accurate prediction of individual CRC risk, which could contribute to the refinement of current screening and prophylactic programs. The aim of this case-control study was to explore the association between SIRT1 polymorphisms and CRC risk. Methods: We analyzed three SNPs-rs12778366 (T/C), rs3758391 (C/T), and rs7895833 (A/G)-in the promoter region of th

SUBMITTER: Klusek J 

PROVIDER: S-EPMC12156903 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature