Examining the Role of Extrachromosomal DNA in 1,216 Lung Cancers.

ABSTRACT: The role of extrachromosomal DNA (ecDNA) in lung cancer, particularly in subjects who never smoked (LCINS), remains unclear. Examination of 1,216 whole-genome-sequenced lung cancers identified ecDNA in 18.9% of patients. Recurrent amplification of MDM2 and other oncogenes via ecDNA possibly drives a LCINS subset. Tumors harboring ecDNA showed worse overall survival than tumors harboring other focal amplifications. A strong association with whole-genome doubling suggests most ecDNA reflects genomic instability in treatment-naïve lung cancer.

SUBMITTER: Khandekar A 

PROVIDER: S-EPMC12157361 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature