Neurogenesis-dependent transformation of hippocampal memory traces during systems consolidation.

ABSTRACT: Memories for events (i.e., episodic memories) change qualitatively with time. Systems consolidation theories posit that organizational changes accompany qualitative shifts in memory resolution, but differ as to the locus of this reorganization. Whereas some theories favor inter-regional changes in organization (e.g., hippocampus→cortex; multiple trace theory), others favor intra-regional reorganization (e.g., within-hippocampus; trace transformation theory). Using an engram tagging and manipulation approach in mice, here we provide evidence that intra-regional changes in organization underlie shifts in memory resolution. We establish that contextual fear memories lose resolution as a function of time, with mice exhibiting conditioned freezing in both the training apparatus (context A) and

SUBMITTER: Golbabaei A 

PROVIDER: S-EPMC12157470 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature