Dendritic inhibition terminates plateau potentials in CA1 pyramidal neurons.

ABSTRACT: In CA1 pyramidal neurons (CA1-PYRs), plateau potentials control synaptic plasticity and the emergence of place cell identity. Here, we show that dendritic inhibition terminates plateaus in an all-or-none manner. Plateaus were initially resistant to inhibition but became increasingly susceptible to termination as they progressed. Between two distinct subtypes of dendrite-targeting interneurons, OLM^Ndnf generated slower postsynaptic currents that terminated plateaus more effectively than OLM^α2. Voltage-gated Ca²⁺ channels (VGCCs) were necessary for plateaus, which were prolonged by blocking small-conductance Ca²⁺-activated K⁺ channels (SK). A single-compartment model with these two conductances recapitulated core experimental findings an

SUBMITTER: Vaasjo LO 

PROVIDER: S-EPMC12157498 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature