Cross-species Standardised Cortico-Subcortical Tractography.

ABSTRACT: Despite their importance for brain function, cortico-subcortical white matter tracts are underrepresented in diffusion MRI tractography studies. Their non-invasive mapping is more challenging and less explored compared to other major cortico-cortical bundles. We introduce a set of standardised tractography protocols for delineating tracts between the cortex and various deep subcortical structures, including the caudate, putamen, amygdala, thalamus and hippocampus. To enable comparative studies, our protocols are designed for both human and macaque brains. We demonstrate how tractography reconstructions follow topographical principles obtained from tracers in the macaque and how these translate to humans. We show that the proposed protocols are robust against data quality and preserve aspec

SUBMITTER: Assimopoulos S 

PROVIDER: S-EPMC12157545 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature