Contributions of m6A RNA methylation to germline development in the planarian <i>Schmidtea mediterranea</i>.

ABSTRACT: N ⁶-methyladenosine (m⁶A) is one of the most prevalent post-transcriptional modifications of eukaryotic RNA molecules. This post-transcriptional modification is essential in biological contexts ranging from metabolism to cellular differentiation and neuronal function. While the role of m⁶A RNA regulation in the soma of planarian flatworms has been previously studied, the presence and biological relevance of this regulatory pathway in the germline of these or other lophotrochozoans remains unknown. Here, we characterize m⁶A RNA regulation factors in the planarian Schmidtea mediterranea and analyze their function in development of the germline. Enriched expression of orthologs of m⁶A methyltransferase complex components, na

SUBMITTER: Tasaki J 

PROVIDER: S-EPMC12157551 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature