Decay drives RNA abundance regulation using three distinct regulatory mechanisms.

ABSTRACT: RNA decay is essential for maintenance of normal RNA abundances; however how RNA decay is regulated to contribute to changes in RNA abundances is poorly understood. Here, we addressed this question by analyzing rates of RNA abundance change, RNA halflives (t _1/2s), and transcription rates in stimulated Arabidopsis leaf cells. This revealed three mechanisms by which decay influenced RNA abundance changes. First, the biggest changes in RNA abundances resulted from t _1/2 changes that reinforced transcriptional regulation (synergistic). Modest RNA abundance changes arose from a second mechanism in which t _1/2 changes opposed transcriptional regulation (oppositional). Finally, RNA decay alone also contributed to RNA abundance change, and RNA

SUBMITTER: Sorenson RS 

PROVIDER: S-EPMC12157598 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature