Global Landscape of Human Kinase Motifs in Viral Proteomes.

ABSTRACT: The successful establishment of infection relies on an ability to sense and adapt to the host signaling state. One key mechanism of virus-host sensing is host-mediated post-translational modifications of viral proteins. While viral protein phosphorylation by host kinases is known to modulate viral functions, the global prevalence of kinase motifs across diverse viruses, and the signaling pathways they reflect, remains to be systematically explored. Here, we annotated human kinase motifs in 1,505 viral proteomes and uncovered enriched motifs in viral proteins that diverged from patterns observed in human proteins. Integration of our findings with 21,606 viral protein structures and deep mass spectrometry phosphoproteomics of infected human cells revealed that surface-accessible residues wer

SUBMITTER: Alba K 

PROVIDER: S-EPMC12157635 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature