A novel Notch and WNT signaling mechanism contribute to paediatric DCM: a pathway to new therapeutics.

ABSTRACT:

Background

Paediatric Idiopathic dilated cardiomyopathy (iDCM) is a life-threatening disease. The lack of disease-specific animal models limits our understanding of its mechanisms. We previously demonstrated that paediatric iDCM serum-circulating proteins promote pathologic remodeling in vitro, and that secreted frizzled related protein 1 (sFRP1) increases stiffness in cardiomyocytes. Here we investigated the mechanisms by which sFRP1 contributes to iDCM.

Methods

The effect of sFRP1 in combination with isoproterenol (ISO) (to recapitulate the increase in circulating catecholamine observed in paediatric iDCM) was evaluated in neonatal rat ventricular myocytes (in vitro), and in neonatal rats through intraperitoneal injections (in vivo). Function and molec

SUBMITTER: Nyarko OO 

PROVIDER: S-EPMC12157673 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature