Comparative transcriptomics of iPSC-derived cardiomyocytes in a high and a low altitude population.

ABSTRACT: Tibetan adaptation to high-altitude hypoxia remains a classic example of Darwinian selection in humans. To identify adaptive traits that might have evolved in Tibetans in response to long-term exposure to hypoxia, we previously established a library of induced pluripotent stem cells (iPSCs), derived from Tibetan and Han Chinese individuals, as a robust model system for the exploration of condition-specific molecular and cellular responses. We used this system to characterize and compare the transcriptome of iPSC-derived endothelial cells and found that angiogenesis, energy metabolism and immune pathways differ between the cell lines from these two populations. Here, we harness the same experimental system to characterize and compare the transcriptome of iPSC-derived cardiomyocytes in Tibet

SUBMITTER: Gray OA 

PROVIDER: S-EPMC12157700 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature