C-Myc inhibits macrophage antimycobacterial response in <i>Mycobacterium tuberculosis</i> infection.

ABSTRACT: Mycobacterium tuberculosis (MTB) is a major global cause of mortality worldwide, responsible for over a million deaths annually. Despite this burden, natural immunity prevents disease in more than 90% of exposed individuals. Previous studies have identified interferon-gamma (IFN-γ) as a key regulator of innate immune defense against MTB. Here, we investigate the impact of IFN-γ timing on macrophage-mediated control of MTB infection. We demonstrate that IFN-γ exposure before infection enhances macrophage antibacterial activity, whereas post-infection exposure does not. Further investigation into this phenotype revealed a strong association between c-Myc signaling and macrophage function in MTB control, as identified using unbiased in vitro systems approaches. Given the challenge of p

SUBMITTER: Sarti E 

PROVIDER: S-EPMC12157703 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature