A Cross-Sectional Study on Protein Substitutes for Paediatric Phenylketonuria Diet: Time to Pay Attention.

ABSTRACT: Introduction: Protein substitutes (PSs) free of phenylalanine (Phe) represent the primary source of proteins and micronutrients in dietary management of classical Phenylketonuria (PKU). Over the last few years, the composition of PSs has undergone rapid and significant improvements, including the development of slow-release amino acid technologies, the introduction of glycomacropeptide-based products, as well as enhancements in taste and the variety of available formulations. However, their micronutrient content has received limited attention. This work aims to analyse the micronutrient composition of all PS formulations available in Italy for paediatric PKU patients and compare their micronutrient contribution to the recommended dietary allowance (RDA) and assess variability among

SUBMITTER: Tummolo A 

PROVIDER: S-EPMC12157769 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature