Natural Bicarbonate Water Might Enhance Nitrogen Balance and Lipid Metabolism and Improve Calcium Balance: A Full Quantitative Targeted Metabolomics Study in Rats.

ABSTRACT: Background/Objectives: Drinking natural bicarbonate water (NBW) has been associated with decreased bone resorption, improved lipid profile, and reduced cardiovascular risk. However, the specific molecular mechanisms underlying these effects remain unclear. Methods: Twenty 10-month-old female Sprague Dawley rats were randomly allocated to two experimental groups; one received purified water (PW) and the other was administered NBW over a three-month intervention period. The liver's metabolic properties were analyzed using a comprehensive quantitative targeted metabolomics technique. Results: Sixty-nine differential metabolites (67 upregulated and 2 downregulated) were detected in the NBW group compared to the PW group. These metabolites included 34 amino acids, 11 carboh

SUBMITTER: Luo J 

PROVIDER: S-EPMC12157924 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature