A mathematical model that predicts human biological age from physiological traits identifies environmental and genetic factors that influence aging.

ABSTRACT: Why people age at different rates is a fundamental, unsolved problem in biology. We created a model that predicts an individual's age from physiological traits that change with age in the large UK Biobank dataset, such as blood pressure, lung function, strength, and stimulus-reaction time. The model predicted a person's age with best accuracy when it heavily weighted traits that together query multiple organ systems, arguing that most or all physiological systems (lung, heart, brain, etc.) contribute to the global phenotype of chronological age. Differences between calculated 'biological' age and chronological age (∆Age) appear to reflect an individual's relative youthfulness, as people predicted to be young for their age had a lower subsequent mortality rate and a higher parental age at d

SUBMITTER: Libert S 

PROVIDER: S-EPMC12158426 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature