Circulating tumor DNA profiling for non-invasive genomic analysis in Indian lung cancer patients: A real-world experience.

ABSTRACT:

Background

Liquid biopsy assays are an important tool for non-invasive detection of genetic alterations, providing an effective alternative to traditional tissue biopsies. The study aimed to investigate the utility of ctDNA based next generation sequencing for clinical management of lung cancer patients from India.

Methods

We conducted ctDNA targeted sequencing on 425 lung cancer patients from India using 50 gene oncomine precision assay. The assay was validated employing 7 controls and 77 clinical samples, and the performance of the assay was evaluated. The concordance analysis with matched tissue biopsy samples was performed on 162 cases.

Results

Among the 425 lung cancer samples, 47 % harbored at least one mutation. EGFR was the most frequently altered gene

SUBMITTER: Jha P 

PROVIDER: S-EPMC12158504 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature