Biologics in IgE-mediated food allergy: A systematic review and meta-analysis of interventional studies.

ABSTRACT:

Background and aims

IgE-mediated food allergy (FA) is a major healthcare problem, affecting millions of children and adults worldwide. FA management usually involves elimination diets; however, there is increasing interest in alternative strategies that enable individualized optimal approaches. Yet, there is little consensus on the optimal strategies for managing FA. This review aimed to evaluate the effectiveness and safety of biologics, including omalizumab (OMA), as monotherapy or in combination with oral immunotherapy (OIT), for FA management.

Methods

A systematic review (SR) and meta-analysis (MA) was conducted, searching 10 international electronic databases (from their start to May 2024) for randomized controlled trials (RCTs) assessing biologics in FA patients. The o

SUBMITTER: Nurmatov UB 

PROVIDER: S-EPMC12158532 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature