Reframing type 1 diabetes through the endocannabinoidome-microbiota axis: a systems biology perspective.

ABSTRACT: Type 1 diabetes (T1D) has long been recognized as a T-cell-driven autoimmune disease. However, growing evidence highlights the involvement of metabolic, inflammatory, and gut microbiota-related factors in its progression. The endocannabinoid system (ECS), a key regulator of immune and metabolic homeostasis, has been increasingly implicated in autoimmune pathophysiology, particularly through its interactions with gut-derived metabolites. This hypothesis article underscores the need to reframe T1D pathophysiology by integrating ECS dysfunction, gut dysbiosis, and metabolic imbalances into a systems biology framework. The proposed Endocannabinoidome-Microbiota (ECBoM) model highlights a shared hallmark of autoimmunity-SCFA depletion, increased intestinal permeability, and ECS dysregulation-as

SUBMITTER: Lukowski W 

PROVIDER: S-EPMC12158731 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature