Molecular mechanisms of deer antler in promoting osteogenic differentiation of human mesenchymal stem cells via JUN modulation.

ABSTRACT:

Background

Traditional Chinese medicine and food deer antler has been extensively used in bone regeneration, but its molecular mechanisms remain poorly understood. Preliminary investigations suggest deer antler contains bioactive compounds that influence osteogenic differentiation and immune microenvironments.

Purpose

To elucidate the molecular mechanisms of deer antler in promoting human mesenchymal stem cell (hMSC) osteogenic differentiation, focusing on JUN downregulation and immune microenvironment modulation using bioinformatics and molecular docking approaches.

Methods

Chemical components and targets were identified using the BATMAN-TCM database. Differentially expressed genes (DEGs) related to osteogenic differentiation were analyzed using Gene Expression Omnib

SUBMITTER: Yu C 

PROVIDER: S-EPMC12158746 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature