System vaccinology analysis of predictors and mechanisms of antibody response durability to multiple vaccines in humans.

ABSTRACT: We performed a systems vaccinology analysis to investigate immune responses in humans to an H5N1 influenza vaccine, with and without the AS03 adjuvant, to identify factors influencing antibody response magnitude and durability. Our findings revealed a platelet and adhesion-related blood transcriptional signature on day 7 that predicted the longevity of the antibody response, suggesting a potential role for platelets in modulating antibody response durability. As platelets originate from megakaryocytes, we explored the effect of thrombopoietin (TPO)-mediated megakaryocyte activation on antibody response longevity. We found that TPO administration enhanced the durability of vaccine-induced antibody responses. TPO-activated megakaryocytes also promoted survival of human bone-marrow plasma cel

SUBMITTER: Cortese M 

PROVIDER: S-EPMC12158788 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature