Phenome-wide investigation of dietary and health outcomes associated with bitter taste receptor gene TAS2R38.

ABSTRACT:

Background

Bitter taste receptor gene TAS2R38 determines our ability to perceive the bitter substances phenylthiocarbamide (PTC) and propylthiouracil (PROP). Despite being extensively investigated, its potential correlations with dietary and health outcomes remain inconclusive. This study aims to validate previous findings observed in small studies and explore novel associations using publicly available summary results statistics from large-scale genome-wide association studies (GWAS).

Methods

We examine the associations between three TAS2R38 variants (rs713598, rs1726866, and rs10246939) and 139 food liking traits and 29 food intake traits using GWAS data from the UK Biobank (N up to 445,779 individuals of European ancestry). We further search for their associations with he

SUBMITTER: Brito Nunes C 

PROVIDER: S-EPMC12158849 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature