Trends and hotspots in targeted therapy resistance research for renal cell carcinoma: a bibliometric and visualization analysis.

ABSTRACT:

Background

Molecular targeted therapies have shown considerable efficacy in treating metastatic renal cell carcinoma (mRCC). However, many patients still experience tumor recurrence or metastasis due to drug resistance. Despite extensive research on resistance mechanisms, there is a lack of comprehensive bibliometric studies examining the overall characteristics of targeted therapy resistance in renal cell carcinoma.

Materials and methods

Publications on resistance to targeted therapy in renal cell carcinoma were identified from the Web of Science Core Collection (WoSCC) from June 2004 to November 2024. The English-language literature was analyzed using bibliometric tools, including VOSviewer and CiteSpace, to examine publication trends, active countries/regions, key authors

SUBMITTER: Wang Z 

PROVIDER: S-EPMC12158908 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature