Embryo-derived trypsin-induced calcium entry is inhibited by endometrial infertility factor, LEFTY2.

ABSTRACT:

Introduction

A transient window of uterine receptivity ensures that embryos implant in an optimal endometrial environment. Failure to establish or premature closure of the implantation window is thought to be a major cause of infertility, which affects many couples globally. Embryos release trypsin, which designates its developmental potential and plays a crucial role in implantation. Calcium (Ca²⁺) signalling participates in receptivity and is thus a prerequisite for embryo implantation. Left-right determination factor 2 (LEFTY2) is a negative regulator of endometrial receptivity and is associated with unexplained infertility. We hypothesize that LEFTY2 impedes Ca²⁺ entry induced by trypsin in endometrial cells.

Methods

In silico analysis was pe

SUBMITTER: Yang Z 

PROVIDER: S-EPMC12158927 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature