The effect of conditioning regimen intensity on periodontal health in haematopoietic cell transplantation recipients: a 5-year multicentre prospective cohort study.

ABSTRACT:

Objectives

To evaluate periodontal health and its association with conditioning intensity over five years post-HCT.

Materials and methods

This multicentre prospective study included 104 patients from two Dutch centres. Probing pocket depth (PPD), bleeding on probing (BOP), and buccal gingival recession (GR) were assessed pre-HCT and at three (n = 34), six (n = 45), twelve (n = 46), eighteen months (n = 30), and five years (n = 36) post-HCT. Regression models evaluated associations with conditioning intensity and time since HCT.

Results

HCT recipients had a median age of 58 years; 56% were male, and 59% received an allogeneic transplant. At baseline, mean PPD was 2.3 mm (31% had PPD ≥ 6 mm), mean BOP was 23%, and the median number of teeth with GR ≥ 1 mm was nine. Cond

SUBMITTER: van Gennip LLA 

PROVIDER: S-EPMC12159097 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature