Ventral hippocampus neurons encode meal-related memory.

ABSTRACT: The ability to encode and retrieve meal-related information is critical to efficiently guide energy acquisition and consumption, yet the underlying neural processes remain elusive. Here we reveal that ventral hippocampus (HPCv) neuronal activity dynamically elevates between eating bouts during meal consumption and this response is predictive of performance in a foraging-related memory test for the spatial location of a previously consumed meal. Targeted recombination-mediated ablation of HPCv meal-responsive neurons impairs meal location memory without influencing food motivation or spatial memory for escape location. These HPCv meal-responsive neurons project to the lateral hypothalamic area (LHA) and are enriched in serotonin 2a receptors (5HT2aR). Either chemogenetic silencing of HPCv-t

SUBMITTER: Decarie-Spain L 

PROVIDER: S-EPMC12159138 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature