Exploring the effects of exercise on immune cell function and tumour infiltration in patients with breast cancer receiving neoadjuvant chemotherapy - a feasibility trial.

ABSTRACT: Pre-clinical studies have shown that exercise can decrease tumour growth through mobilisation, activation, and increased tumour infiltration of natural killer (NK) and CD8⁺ T cells. It is currently unclear whether this can be extrapolated to patients. Therefore, a pilot study was set up to examine the feasibility of obtaining an additional study biopsy and to generate preliminary data on the potential effects of exercise on peripheral immune cell function and tumour immune infiltration. Twenty patients with stage I-III breast cancer receiving neoadjuvant chemotherapy were included (participation rate: 27%). Patients were randomised into the intervention group receiving a six-week supervised aerobic and resistance exercise program or the control group. Blood samples and tumour bi

SUBMITTER: Ubink A 

PROVIDER: S-EPMC12159211 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature