Epigenomic insights into the immune regulatory mechanism of GBP4L in poultry.

ABSTRACT: High-temperature environments induce heat stress in poultry, leading to compromised immune function and reduced disease resistance. In the Dexamethasone-induced stress-related immune suppression model in chickens, both transcriptomic and proteomic analyses revealed significantly low expression of GBP4L, highlighting its potential as a key target for combating stress. It is currently unclear whether GBP4L can alleviate the heat stress response in the body. We conducted this study to explore the role of GBP4L in stress resistance. First, to evaluate the role of GBP4L in immune function, we established an inflammatory cell model via Lipopolysaccharide (LPS) treatment and then generated both a pcDNA3.1-EGFP-GBP4L plasmid and a si-GBP4L interference fragment for transfection into HD11 model cel

SUBMITTER: Zhang H 

PROVIDER: S-EPMC12159214 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature