Engineering 3D-BMSC exosome-based hydrogels that collaboratively regulate bone microenvironment and promote osteogenesis for enhanced cell-free bone regeneration.

ABSTRACT: Large bone defects are a significant clinical challenge due to their frequent failure to heal spontaneously. Recently, BMSC-derived exosomes (Exo) based cell-free bone regeneration offer several distinct advantages over BMSCs themselves in the repair of damaged tissue, including enhanced repair ability and superior biocompatibility, which can be further augmented under 3D-cultured conditions. However, their therapeutic efficacy for bone regeneration is significantly constrained by hypoxic bone microenvironment and short retention time in bone defect region. Thus, judiciously regulating bone microenvironment and extending retention time are crucial for bone regeneration. Herein, we developed Superparamagnetic Iron Oxide Nanoparticles (SPION) -modified 3D-cultured Exo, termed as 3D-SExo, to

SUBMITTER: Xiang K 

PROVIDER: S-EPMC12159235 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature