Incomplete reverse remodeling in pulmonary hypertension-induced right ventricular dysfunction in aged mice.

ABSTRACT: Right ventricular (RV) function is the strongest predictor of survival in pulmonary hypertension (PH) and age-related heart disease; however, no therapies improve RV function. Understanding how the RV undoes pathological remodeling (reverse remodeling) might aid in identifying therapies, particularly in aging populations in which RV failure is significant. Our objective was to determine if the aged RV can undergo reverse remodeling following the resolution of pathological afterload by pulmonary hypertension (PH). We exposed male and female aged (18-21 months) C57BL/6 mice to hypobaric hypoxia (HH) for 4 weeks to model PH before returning the mice to normoxia for three (WK3RR) or six (WK6RR) weeks. HH stimulated RV hypertrophy and fibrosis which were attenuated with WK3RR and WK6RR. Activat

SUBMITTER: McNair BD 

PROVIDER: S-EPMC12159252 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature