Induction of haemodynamic travelling waves by glial-related vasomotion in a rat model of neuroinflammation: implications for functional neuroimaging.

ABSTRACT:

Background

Cerebral haemodynamics are crucial for brain homoeostasis and serve as a key proxy for brain activity. Although this process involves coordinated interaction between vessels, neurons, and glial cells, its dysregulation in neuroinflammation is not well understood.

Methods

We used in vivo mesoscopic functional ultrasound imaging to monitor cerebral blood volume changes during neuroinflammation in male rats injected with lipopolysaccharide (LPS) in the visual cortex, under resting-state or visual stimulation, combined to advanced ex vivo techniques for glial cell reactivity analysis.

Findings

Cortical neuroinflammation induced large oscillatory haemodynamic travelling waves in the frequency band of vasomotion (∼0.1 Hz) in both anaesthetized and awake rats. Vas

SUBMITTER: Pereira M 

PROVIDER: S-EPMC12159494 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature