Organ/space surgical site infection and long-term outcomes of rectal cancer surgery: retrospective population-based cohort study.

ABSTRACT:

Background

Anastomotic leak and subsequent organ/space surgical site infection (O/S-SSI) after colorectal cancer surgery are associated with poor short-term outcomes; however, the evidence regarding long-term outcomes is inconclusive. This population-based retrospective cohort study aimed to evaluate the association between O/S-SSI and both tumour recurrence and long-term survival after curative rectal cancer surgery.

Methods

Data was obtained for all adults who underwent curative oncological resection of the rectum in the periods 2011-2012 and 2015-2016 (n = 2208) in Spain. Multivariable analysis (Cox proportional hazards model) was used to evaluate the effects of clinical and pathological characteristics, as well as the occurrence of O/S-SSI, on recurrence and survival.

SUBMITTER: Matallana C 

PROVIDER: S-EPMC12159736 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature