Sarcopenia in patients with metastatic breast cancer: A systematic review and meta-analysis.

ABSTRACT:

Background

Sarcopenia is associated with poor treatment outcomes and survival in early breast cancer and other cancer types. This systematic review and meta-analysis evaluated sarcopenia's prevalence and clinical implications for metastatic breast cancer-an area that remains underexplored.

Methods

A systematic literature review searched CINAHL, Cochrane Library, Embase, and Ovid MEDLINE for studies published before October 2024. A meta-analysis using a random- or fixed-effects model calculated mean differences in skeletal muscle index (SMI) and assessed the association with progression-free and overall survival. The study protocol was registered on PROSPERO (CRD42024557390).

Results

Fourteen studies involving 1472 participants with metastatic breast cancer were includ

SUBMITTER: Jang MK 

PROVIDER: S-EPMC12159878 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature