JNK signaling coordinates epithelial cell turnover through exocytosis in <i>Drosophila</i> ribosomal protein mutants.

ABSTRACT: Robust tissue growth is orchestrated by the precise coordination of cell death and cell proliferation. In the developing wing pouches of Drosophila Minute/+ animals, both cell death and compensatory cell proliferation are increased, thereby contributing to robust growth of mutant tissue. Here, we show that JNK-mediated elevation of exocytosis in dying cells is crucial for triggering cell turnover in M/+ wing morphogenesis. Mechanistically, elevated JNK signaling in dying cells upregulates exocytosis-related genes and Wingless (Wg), leading to enhanced Wg secretion. Notably, increased exocytosis promotes caspase activation via an exocytosis-Dronc amplification loop, sustaining apoptotic signaling while reinforcing Wg secretion through Dronc activation. Furthermore, this exocyt

SUBMITTER: Akai N 

PROVIDER: S-EPMC12159887 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature