Impact of Y chromosome loss on the risk of Parkinson's disease and progression.

ABSTRACT:

Background

Loss of Y chromosome (LOY), an age-related somatic mutation, is associated with various age-related diseases, but its role in the onset and progression of Parkinson's disease (PD) remains unclear. This study investigated the relationship between blood LOY levels and the risk of PD onset and progression.

Methods

We estimated the LOY level for each male participant based on genome-wide arrays or whole genome sequencing data. We performed Cox proportional hazards regression analysis among 222,598 male participants in the UK Biobank and linear mixed model analysis involving 2574 male individuals with PD across 14 cohorts, encompassing 19,562 visits. In the Parkinson's Progression Markers Initiative (PPMI) cohort, we further compared brain structure using T1-weighted m

SUBMITTER: Wang J 

PROVIDER: S-EPMC12159889 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature