The efficacy and safety of fecal microbiota transplantation in the treatment of sarcopenia: a retrospective study.

ABSTRACT:

Background

Sarcopenia, a prevalent geriatric syndrome, is influenced by factors such as inflammation, immune deficiency, and oxidative stress. In elderly individuals, alterations in the microbiome, including reduced biodiversity and functional changes, significantly contribute to the progression of the disease. Targeting the gut-muscle axis has emerged as a promising therapeutic strategy to mitigate age-related muscle atrophy and dysfunction.

Methods

This study employed fecal microbiota transplantation (FMT) to restore intestinal homeostasis in patients with sarcopenia. Muscle mass was measured using bioelectrical impedance analysis, while muscle function was assessed through grip strength and the five-time sit-to-stand test. Inflammatory markers, including tumor necrosis fa

SUBMITTER: Yang B 

PROVIDER: S-EPMC12160374 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature