Insight into the metabolic shifts in Graves' hyperthyroidism: a study of acylcarnitine and lipid profiles.

ABSTRACT:

Objective

Graves' disease increases metabolism and leads to net lipid degradation. Circulating acylcarnitines reflect lipid metabolism and the state of fatty acid oxidation in individuals. The aim of this study was to explore the lipid and acylcarnitine profiles in patients with Graves' disease.

Methods

Seven lipids/apolipoproteins and 23 acylcarnitines were analysed in 100 newly diagnosed Graves' disease patients and validated in another 51 patients. Both groups were age- and sex-matched with healthy subjects.

Results

The hyperthyroid Graves' disease patients (n = 88) from the main cohort (78 females, median age 42 (17-67) years) had significantly (P < 0.05) higher levels of medium- and long-chain acylcarnitines, and lower levels of short-chain acylcarnitines, compar

SUBMITTER: Neset MT 

PROVIDER: S-EPMC12160452 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature