Genomewide linkage scan for bipolar-disorder susceptibility loci among Ashkenazi Jewish families.

ABSTRACT: The relatively short history of linkage studies in bipolar disorders (BPs) has produced inconsistent findings. Implicated regions have been large, with reduced levels of significance and modest effect sizes. Both phenotypic and genetic heterogeneity may have contributed to the failure to define risk loci. BP is part of a spectrum of apparently familial affective disorders, which have been organized by severity. Heterogeneity may arise because of insufficient data to define the spectrum boundaries, and, in general, the less-severe disorders are more difficult to diagnose reliably. To address the inherent complexities in detecting BP susceptibility loci, we have used restricted diagnostic classifications and a genetically more homogeneous (Ashkenazi Jewish) family collection to perform a 9-c

SUBMITTER: Fallin MD 

PROVIDER: S-EPMC1216055 | biostudies-literature | 2004 Aug

REPOSITORIES: biostudies-literature