Ugonin P mitigates osteolytic bone metastasis by suppressing MDK via upregulating miR-223-3p expression.

ABSTRACT: Bone metastasis is a significant complication in advanced-stage cancers, especially breast and lung malignancies, profoundly influencing prognosis and quality of life. Osteolytic bone metastasis contains multiple interactions between cancer cells and the bone microenvironment, driving osteoclast-mediated bone resorption and deterioration while releasing growth factors that promote tumor progression. Current treatments, including surgery, radiation, and chemotherapy, often result in severe side effects, highlighting the need for effective, targeted therapies. Ugonin P, a natural compound derived from Helminthostachys zeylanica, known for its anti-inflammatory and anticancer properties. However, the effects of Ugonin P on osteolytic bone metastasis remain unclear. Our findings demonst

SUBMITTER: Law YY 

PROVIDER: S-EPMC12160927 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature