Theta-Gamma Subthalamic Stimulation for Verbal Fluency in Parkinson's Disease: A Randomized, Crossover Trial.

ABSTRACT:

Background

High-frequency deep brain stimulation (DBS) of the subthalamic nucleus (STN) improves Parkinson's disease (PD) motor symptoms but may deteriorate verbal fluency (VF). Theta stimulation showed potential cognitive benefits associated with motor worsening.

Objectives

This randomized, double-blind, crossover study evaluated the efficacy and safety of combined theta-gamma frequency stimulation on VF in PD patients with STN-DBS.

Methods

Patients were randomized 1:1 for standard or theta-gamma stimulation. VF, motor, and non-motor symptoms were assessed at baseline, 1 h, and 1 month after each period. Data were analyzed using a linear mixed-effects model.

Results

Twelve patients completed the study. Non-episodic (P = 0.038) and episodic VF (P = 0.030) impro

SUBMITTER: Imbalzano G 

PROVIDER: S-EPMC12160985 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature