Study protocol for the Outcomes Post-Treatment: Impact on Motor Impairment of Sleep Efficiency in Spinal Cord Injury (OPTIMISE SCI) - a randomised controlled trial.

ABSTRACT:

Introduction

Spinal cord injury (SCI) has been linked to increased frequencies of sleep-related breathing disorders (SRBDs) (≤50% after paraplegia and ≤90% following tetraplegia). However, SRBDs have been under-recognised and undertreated among individuals with SCI. The OPTIMISE SCI (Outcomes Post Treatment: Impact on Motor Impairment of Sleep Efficiency in SCI) is an ongoing phase 3 clinical trial focused on the effects of the early use of continuous positive airway pressure (CPAP) therapy to treat individuals with moderate-to-severe SRBDs in the acute/subacute stage after SCI.

Methods and analysis

A total of 44 participants with SCI who are newly diagnosed with moderate-to-severe SRBD are randomised into early CPAP th

SUBMITTER: Furlan JC 

PROVIDER: S-EPMC12161322 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature