Drivers of vessel progenitor fate define intermediate mesoderm dimensions by inhibiting kidney progenitor specification.

ABSTRACT: Proper organ formation depends on the precise delineation of organ territories containing defined numbers of progenitor cells. Kidney progenitors reside in bilateral stripes of posterior mesoderm that are referred to as the intermediate mesoderm (IM). Previously, we showed that the transcription factors Hand2 and Osr1 act to strike a balance between the specification of the kidney progenitors in the IM and the vessel progenitors in the laterally adjacent territory. Recently, the transcription factor Npas4l - an early and essential driver of vessel and blood progenitor formation - was shown to inhibit kidney development. Here we demonstrate how kidney progenitor specification is coordinated by hand2, osr1, and npas4l. We find that npas4l and the IM marker pax2a are transiently co-expressed

SUBMITTER: Perens EA 

PROVIDER: S-EPMC12161456 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature