The Tumor-Associated Neutrophils-Related Signatures Predict Prognosis and Indicate Immune Landscape in Colorectal Carcinoma.

ABSTRACT: Background: Tumor-associated neutrophils (TANs), a major immune cell type in the tumor microenvironment (TME), are associated with antitumor or pro-tumor phenotypes. A wealth of evidence evidences demonstrated that the content of TANs has been implicated in the pathogenesis of cancer and may be ideal targets for cancer therapy. In this study, we identified TANs-related genes to construct a prognostic model and evaluated its potential as a biomarker for predicting prognosis and immunotherapeutic response in colorectal carcinoma (CRC). Methods: Kaplan-Meier survival curves were used to assess the impact of TANs infiltration on patient survival. Weighted Gene Co-Expression Network Analysis (WGCNA) identified genes associated with TANs. Univariate Cox regression and least absolut

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12162164 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature