Trifolin inhibits the calcium-driven contraction pathway in vascular smooth muscle.

ABSTRACT: Trifolin, a bioactive component of the Qingda granule, has demonstrated significant antihypertensive potential; however, its precise mechanisms of action remain largely unknown. This study aimed to investigate the antihypertensive effects of trifolin and unravel its underlying molecular mechanisms. The influence of trifolin on vascular contraction and relaxation and its regulatory effects on ion channels were evaluated through a vascular tension experiment. Morphological changes in the aortic tissues of mice with angiotensin Ⅱ-induced hypertension and the expression profiles of contraction-associated proteins were analyzed via hematoxylin-eosin staining and immunohistochemistry. Additionally, trifolin's impact on calcium ion dynamics and contraction-associated protein expression in angiote

SUBMITTER: Li R 

PROVIDER: S-EPMC12162279 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature