Construction of epilepsy diagnosis model based on cell senescence-related genes and its potential mechanism.

ABSTRACT:

Introduction

Epilepsy is a chronic brain disease with a certain degree of neurodegeneration and is caused by abnormal discharges of neurons. The mechanism of cell senescence has garnered increasing attention in neurodegenerative diseases. However, the role of cell senescence in the onset and progression of epilepsy is unclear. Therefore, this study constructed a diagnostic model of epilepsy based on cellular senescence-related genes (CSRGs) to analyze their role in disease pathogenesis.

Methods

The differentially expressed genes (DEGs) were screened from the epileptic sample dataset of the gene expression omnibus (GEO) database, and the cellular senescence-related DEGs (CSRDEGs) related to epilepsy were identified by CSRGs crossover. The functional enrichment characte

SUBMITTER: Gong X 

PROVIDER: S-EPMC12162300 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature