Flexible iron: disorder in the ironome brings order to protein structure and function.

ABSTRACT: Iron is one of the most abundant elements on earth. The most recognized role of iron in living organisms is its incorporation in the heme-containing protein hemoglobin, which is abundantly found in the red blood cells that facilitate the oxygen transportation throughout the body. In fact, about 70% of organism's iron is found in hemoglobin. However, besides being essential for oxygen transport and serving as a crucial component of the molecular oxygen-carrying proteins hemoglobin and myoglobin, iron has a wide range of other biological functions. It is involved in numerous metabolic and regulatory processes and therefore is indispensable for almost all living organisms. Since iron enzymes are responsible for most of the redox metallo-catalysts, it is not surprising that 6.5% of all human e

SUBMITTER: Uversky VN 

PROVIDER: S-EPMC12162314 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature