An immune-related seven-gene signature for predicting lymph node metastasis in breast cancer.

ABSTRACT:

Background

Breast cancer (BC) is the leading malignant tumors among females worldwide, which serves as a common chronic disease with several acute postoperative complications, including upper limb edema, hemorrhage, flap necrosis, effusion and so on. A majority of BC patients have lymph node metastasis, suffering from a poor prognosis. The immune system has been reported to participate in regulating BC lymph node metastasis. This study aimed to search for immune-related biomarkers for predicting BC lymph node metastasis.

Methods

1057 BC patients were acquired from The Cancer Genome Atlas (TCGA) database as the training dataset while 327 BC patients were obtained from GSE20685 as the validation dataset. We get 2,175 immune genes from four immune-related gene sets. We divided

SUBMITTER: Hu Y 

PROVIDER: S-EPMC12162330 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature