Congrong Shujing Granules ameliorates mitochondrial associated membranes to against MPP⁺-induced neurological damage in the cellular model of Parkinson's disease.

ABSTRACT:

Context

Congrong-Shujing Granules (CRSJG) are known to protect dopaminergic neurons in Parkinson's disease (PD), and the mechanism may be related to the improvement of mitochondria-associated membranes (MAMs).

Objective

To investigate the impact of CRSJG-medicated serum on MAMs in the 1-methyl-4-phenylpyridinium (MPP⁺)-induced PD cell model.

Materials and methods

Human neuroblastoma (SH-SY5Y) cells were treated with 1,000 μmol/L MPP⁺ for 24 h, resulting in three experimental groups: MPP⁺, CRSJG, and 2-APB. The MPP⁺ group received blank serum, CRSJG group was treated with CRSJG-medicated serum, and the 2-APB group was given 100 μmol/L 2-APB. An untreated control group was also included. Serum pharmacokinetics for the CRSJG gr

SUBMITTER: Zhang C 

PROVIDER: S-EPMC12162334 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature